Mutech and RTD card installation for IW6
ISC Webmaster2019-10-22T20:13:07-05:00This document contains a step by step guide for the installation of the Mutech video card used for contractility and diameter measurements.
G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
ionoptix2019-11-09T22:16:04-05:00Raake, P. W., Vinge, L. E., Gao, E., Boucher, M., Rengo, G., Chen, X., DeGeorge Jr., B.R., Matkovich, S., Houser, S.R., Most, P., Eckhart, A.D., Dornll, G.W., and Koch, W. J. (2008). Circulation Research, 103(4), 413-422
Techniques and Best Practices for Cardiomyocyte Isolation
ionoptix2019-12-06T14:33:27-05:00Ronglih Liao and Davor Pavlovic discuss techniques for isolating myocytes using both traditional and Langendorff-free methodologies.
The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension.
ionoptix2019-10-22T19:56:51-05:00The control of Ca2+ influx and NFATc3 signaling in arterial smooth muscle during hypertension. Nieves-Cintrón M, Amberg GC, Navedo MF, Molkentin JD, Santana LF Abstract: Many excitable cells express L-type Ca2+ channels (LTCCs), which participate in physiological and pathophysiological processes ranging from memory, secretion, and contraction to epilepsy, heart failure, and hypertension. Clusters of LTCCs can operate in a PKCα-dependent, high open probability mode that generates sites of sustained Ca2+ [...]
Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T.
ionoptix2019-10-22T20:06:59-05:00Overexpression of heat shock protein 27 protects against ischaemia/reperfusion-induced cardiac dysfunction via stabilization of troponin I and T. Lu XY, Chen L, Cai XL, Yang HT Abstract: Aims: Heat shock protein 27 (Hsp27) renders cardioprotection from ischaemia/reperfusion (I/R) injury, but little is known about its role in myofilaments. We proposed that increased expression of Hsp27 may improve post-ischaemic contractile dysfunction by preventing I/R-induced cardiac troponin I (cTnI) and troponin T [...]
Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by ATP-Sensitive K+ Channel Openers
ionoptix2019-10-22T20:00:33-05:00Sulfonylurea Receptor-Dependent and -Independent Pathways Mediate Vasodilation Induced by ATP-Sensitive K+ Channel Openers Adebowale Adebiyi, Elizabeth M. McNally and Jonathan H. Jaggar Abstract: ATP-sensitive K+ (KATP) channel openers are vasodilators that activate both plasma membrane and mitochondrial KATP channels. Here, we investigated the molecular mechanisms by which diazoxide and pinacidil induce vasodilation by studying diameter regulation of wild-type (SUR2+/+) and sulfonylurea receptor 2 deficient (SUR2-/-) mouse myogenic mesenteric arteries. Ryanodine [...]
Leptin Attenuates Cardiac Contraction In Rat Ventricular Myocytes. Role of NO.
ionoptix2019-11-09T22:30:17-05:00Nickola, M. W., Wold, L. E., Colligan, P. B., Wang, G., Samson, W. K., & Ren, J. (2000). Hypertension, 36(4), 501-505
Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM?
ionoptix2019-11-09T22:45:06-05:00Bell, J. R., Lloyd, D., Curl, C. L., Delbridge, L. M., & Shattock, M. J. (2009). Experimental Physiology, 94(3), 330-343
Actin cytoskeletal modulation of pressure-induced depolarization and Ca(2+) influx in cerebral arteries.
ionoptix2019-11-09T22:51:50-05:00Gokina, N. I., & Osol, G. (2002). American Journal of Physiology-Heart and Circulatory Physiology, 282(4)
Abnormal Motility in Patients With Ulcerative Colitis: The Role of Inflammatory Cytokines
Andy Henton2019-11-09T22:55:26-05:00Vrees, M. D., Pricolo, V. E., Potenti, F. M., & Cao, W. (2002). Archives of Surgery, 137(4)